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For nearly a quarter century Molecular Biology of the Cell has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter).
The hallmark features of Molecular Biology of the Cell have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features.
It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book.* And for the first time, Molecular Biology of the Cell now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint® presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies―animations, videos, and molecular models―all with voice-over narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well.
By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology.
* There is also a reference edition of Molecular Biology of the Cell, Fifth Edition (ISBN 978-0-8153-4111-6) that contains Chapters 1-25 entirely in printed format.
Content
PART I INTRODUCTION TO THE CELL1. Cells and Genomes2. Cell Chemistry and Biosynthesis3. ProteinsPART II BASIC GENETIC MECHANISMS4. DNA, Chromosomes, and Genomes5. DNA Replication, Repair, and Recombination6. How Cells Read the Genome: From DNA to Protein7. Control of Gene ExpressionPART III METHODS8. Manipulating Proteins, DNA, and RNA9. Visualizing CellsPART IV INTERNAL ORGANIZATION OF THE CELL10. Membrane Structure11. Membrane Transport of Small Molecules and the Electrical Properties of Membranes12. Intracellular Compartments and Protein Sorting13. Intracellular Vesicular Traffic14. Energy Conversion: Mitochondria and Chloroplasts15. Mechanisms of Cell Communication16. The Cytoskeleton17. The Cell Cycle18. ApoptosisPART V CELLS IN THEIR SOCIAL CONTEXT19. Cell Junctions, Cell Adhesion, and the Extracellular Matrix20. CancerChapters 21–25 available on Media DVD-ROM:21. Sexual Reproduction: Meiosis, Germ Cells, and Fertilization22. Development of Multicellular Organisms23. Specialized Tissues, Stem Cells, and Tissue Renewal24. Pathogens, Infection, and Innate Immunity25. The Adaptive Immune System